Everything You Should Know About Paget’s Disease of the Breast


Paget’s disease of the breast, also called Paget’s disease of the nipple, is a rare type of breast cancer.

Symptoms differ from those of other types of breast cancer. Paget’s cells can be found on the surface of the skin of your nipple and areola.

The exact cause of this type of breast cancer isn’t clear. One common theory is that cells from a tumor migrate through the milk ducts to reach the nipple and areola. Some people who develop Paget’s disease of the breast don’t have breast tumors, however.

Keep reading and find out how to identify Paget’s disease of the breast and why diagnosis is often delayed.


For many types of breast cancer, the first symptom is a lump in the breast. Learn what a breast cancer lump feels like.

In Paget’s disease of the breast, there’s another sign you’re likely to notice first. It involves the nipple and areola of your breast, where you might have:

  • redness
  • flaking, crusting, or scaling
  • a tingling or itching sensation

It would be easy to mistake these symptoms as eczema, dermatitis, or some other skin condition. Paget’s disease of the breast is usually found on only one breast, and it won’t respond to topical treatments.

Here are some other clues that signal something more than a skin condition:

  • thickening skin on or near your nipple
  • flattening of your nipple
  • yellowish or bloody discharge from your nipple
  • increasing breast sensitivity, soreness, and pain

Risk factors

There are some factors that may increase your risk of developing breast cancer:

  • You’re a woman over age 50.
  • You have a history of breast cancer or other breast abnormalities.
  • You have close relatives who have had breast or ovarian cancer.
  • You carry mutations of the BRCA1 or BRCA2 genes.
  • You have dense breast tissue.
  • You’ve had previous radiation treatment to your chest.
  • You’re overweight, especially after menopause.
  • You take hormone replacement therapy.
  • You regularly drink a lot of alcohol.


Diagnosis begins with a physical examination. Your doctor will observe the appearance of your breasts, especially around the nipples, and check for lumps or unusual thickening.

It’s likely that your doctor will also order a diagnostic mammogram to look for signs of breast cancer. If there’s anything unusual or unclear, this may be followed by an ultrasound or MRI scan. These detailed images can help pinpoint areas of concern. See examples of mammogram images.

The only way to confirm breast cancer is with a biopsy. This is a procedure in which a needle is used to obtain a small sample of breast tissue from a nipple, areola, or tumor. The sample is then sent to a pathologist who will use a microscope to look for cancer cells.

The large, round appearance of Paget’s cells can confirm the disease. The biopsy can also provide other important details, such as:

  • tumor grade, which indicates how likely it is to grow and spread
  • if the cancer is invasive or noninvasive
  • if it’s positive for hormone receptors (HR) or HER2 gene overexpression


Your oncologist will come up with a treatment plan that takes many factors into account, such as:

  • the size and grade of breast tumor, if any
  • if the cancer has spread (stage)
  • HR and HER2 status
  • if you’ve been treated for cancer in the past
  • your age and general state of health

The type of surgery you have depends on the number and location of tumors, and the relative size of your breast. In breast-conserving surgery, the nipple and areola are removed. This may be a viable option if you don’t have breast tumors.

If you do have breast tumors, removing the whole breast (mastectomy) may be recommended. In this case, your surgeon might also want to biopsy your sentinel lymph nodes to see if the cancer has spread. If so, more extensive lymph node surgery may be necessary.

Surgery might be followed by radiation therapy to target any cancer cells that were missed. Powerful chemotherapy drugs may be used to seek and destroy cancer cells, no matter where they’ve traveled in your body.

If your tumor is HR-positive or positive for overexpression of the HER2 protein, you may be able to take advantage of additional targeted treatments.

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