Most aches and pains aren’t a sign of something serious, but certain symptoms should be checked out. See a doctor if you feel any of these things:

If you get weak or numb in your arm, leg, or face, it can be a sign of a stroke, especially if it’s on one side of your body.

You could also be having a stroke if you can’t keep your balance, feel dizzy, or have trouble walking.

Get help quickly if you suddenly can’t see well, get a bad headache, feel confused, or have problems speaking or understanding.

When it comes to chest pain, it’s better to be safe than sorry.

“Any chest pain, especially accompanied by sweating, pressure, shortness of breath, or nausea, should be evaluated by a medical professional right away,” says Shilpi Agarwal, MD, with One Medical Group in Washington, DC.

Chest pain or pressure can be a sign of heart disease or a heart attack, particularly if you feel it during exertion or while being active. Or, chest pain may mean problems other than with your heart; for example, you have another serious condition, such as a blood clot moving into your lung, Teitelbaum says.

This can be a symptom of a blood clot in your leg. It’s called deep vein thrombosis, or DVT. It can happen after you’ve been sitting for a long time, like on a long plane ride, or if you’re sick and have been in bed a long time.

Several things can cause you to see blood when you pee.

If you have blood in your urine and you also feel a lot of pain in your side or in your back, you may have kidney stones. A kidney stone is a small crystal made of minerals and salts that forms in your kidney and moves through the tube that carries your urine.

Your doctor may take X-rays or do an ultrasound to see the stones. An X-ray uses radiation in low doses to make images of structures inside your body. An ultrasound makes images with sound waves.

Breathing problems should be treated right away. If you’re wheezing, or hear a whistling sound when you breathe, see your doctor.

“Without urgent evaluation, breathing can quickly become labored, and it can be catastrophic if not evaluated and treated quickly,” Agarwal says.

If you feel hopeless or trapped, or think you have no reason to live, get help. Talking to a professional can help you make it through a crisis.

Go to a hospital emergency room or a walk-in clinic at a psychiatric hospital. A doctor or mental health professional will talk to you, keep you safe, and help you get through this tough time.